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In very select, treatment-resistant cases, deep brain stimulation (targeting specific regions of the thalamus) or motor cortex stimulation (placing electrodes on the surface of the brain over the motor cortex) has been investigated as a neuromodulation option

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Organ and tissue growth concerns Because IGF-1 signaling affects cellular growth and proliferation throughout the body and not exclusively in skeletal muscle, there is concern that long-term use of IGF-1 could result in increased growth of other tissues/organs in the body