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As of the time of writing, retatrutide is not licensed for use in the United Kingdom
Thus, BCAAs and BCKAs likely exist in equilibrium in most cases
However, in glutathione synthetase deficiency, because the activity of gamma-glutamyl-cysteine synthetase is regulated via feedback inhibition by glutathione, gamma-glutamyl-cysteine and then L-5-oxoproline are overproduced, resulting in the metabolic acidosis and urinary excretion of this compound at levels several hundred-fold above normal (71
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