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TGR5 is a bile acid receptor signaling through G-protein and activating cAMP production
Additionally, a comprehensive new biochemical flowsheet of the mechanistic pathway for the shuttling of antioxidant-producing HuR protein outside of the nucleus was developed, along with a new comparative biochemical flowsheet analyzing the differences in the response of HuR to sustainable and lethal cell damage
Mechanistically, DMF regulates the expression of factors involved in the de novo cysteine synthesis (CBS), cystine uptake (SLC7A11), and GSH generation (GCLC, GCLM) through NRF2-dependent and independent pathways
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McComsey at Case Western Reserve University
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