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Baumert 4 and Michel Doffoel 1 , (1)Nouvel Hpital Civil, Hpitaux Universitaires De Strasbourg, (2)Hpital Emile Muller, Groupement Hospitalier Rgional Mulhouse Sud Alsace (GHRMSA), (3)Hpital Louis Pasteur, Colmar, (4)Institut Hospitalo-Universitaire (IHU), Ple Hpato-Digestif, Hpitaux Universitaires De Strasbourg, 67000 Strasbourg, France Background: Despite the excellent efficacy of direct-acting antiviral (DAA), in some patients, virological failure can occur associated with resistance associated substitutions (RASs)
Overexpression of the bifunctional l-glutathione synthetase GshF from S
TAF 4, PLB-TAF 3 in Cohort 2 Group 1) qualified for resistance analysis due to persistent viremia (n=19) or VB (n=5)
Typically, patients require 1 to 3 treatments spaced about 30 days apart to achieve the best results
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