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Oxidative stress occurs from normal cellular processes but increasingly from pollution, toxins, stress, and other exposures of modern life
Studies suggest that the VEGF/VEGFR-2 pathway may be particularly relevant, as its activation seems to trigger intracellular signaling cascades that potentially influence endothelial cell migration, proliferation, and survival
Liver detoxification processes involves the use of antioxidants such as glutathione to neutralize toxins in the body
Non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol (PAC) are widely used as non-etiotropic agents in common airways viral infections and hence are both theoretically repurposable for COVID-19
Toppo S, Vanin S, Bosello V, Tosatto SC (2008) Evolutionary and structural insights into the multifaceted glutathione peroxidase (Gpx) superfamily
