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Human Reproduction, 37 (1), 614

Unlike the situation in the POMC-null mice, humans with a lack of POMC expression are unable to survive without glucocorticoid supplementation from birth

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Signs include: running a high fever, skin hot to the touch excessive sweating or dry skin that doesnt sweat muscle cramps rapid pulse or heart rate low blood pressure disorientation irrational or erratic behavior dizziness headache nausea or vomiting dry mouth and intense thirst physical collapse coma Thompson: Extreme heat can also damage the medication and alter the properties of the proteins

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