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Based on the Phase 2 trajectory data (Jastreboff et al., NEJM 2023), individuals at the 12 mg dose had lost approximately 8-10% of their body weight by week 12

[16] Emotional Stress and Hormonal Changes After birth, hormone shifts can make emotions feel intense and unpredictable

Acetyl-L-carnitine (ALC, acetyllevocarnitine) is the naturally occurring acetyl ester of L-carnitine and is the delivery form for both L-carnitine and acetyl groups

Drug addition was cumulatively or non-cumulative as described in the figure legend

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