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Reported effects Increases skin pigmentation (tanning) without requiring UV exposure

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One common SLC1A5 inhibitor, GPNA, along with its derivative V-9032, exerts anti-tumor effects by blocking Gln uptake, inhibiting cell proliferation, and disrupting the intracellular redox state

Likewise, reports of FGF21 increasing water intake and blood pressure in rodents, potentially by stimulating sympathetic pathways (313, 314) do not appear to translate consistently to humans, with one study (293) but no others (183, 244246, 315) suggesting an effect