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A double-blind, randomized, placebo-controlled trial demonstrated that perioperative high-dose intravenous injection of Gln (0.5 g/kg/day, P.O for 3 days) raised plasma Gln concentrations and maintained plasma GSH levels in postoperative patients undergoing cardiopulmonary bypass (CPB) [113]

Lack of approval reflects insufficient human clinical trial data and incomplete evaluation of risks, dosing, and long-term effects

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Its levels vary throughout the body, reaching up to 10 mM in liver cells while other cells maintain millimolar concentrations