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The 14.9% mean weight loss at 68 weeks was unprecedented for a GLP-1 receptor agonist at the time

However, it's important to note that oral semaglutide (Rybelsus) must be taken in the morning on an empty stomach according to its FDA labeling

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Even some mainstream brands are now selling non-FDA-approved versions of these medications for unapproved indications or dosing

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