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Insulin resistance affects both systems
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The mutation transmembrane 6 superfamily member 2 ( TM6SF2 ) gene E167K (rs58542926) emphasizes adenine substitution of guanine (nucleotide position 499), leading to a change in the amino acid position 167(E167K) of glutamate into lysine [96]
Brainstem Gipr -expressing cells have been implicated in suppressing nausea-related behaviours, such as conditioned taste avoidance (CTA), as long-acting GIPR agonists reduced CTA triggered by PYY(3-36), GLP-1 or GDF15 administration 13,14,15,18,19
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