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Activation of apoptosis signalling pathways by reactive oxygen species

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3 Department of Pharmacoeconomics and Social Pharmacy, Poznan University of Medical Sciences, Pozna, Poland Correspondence: Karolina Hoffmann, Department and Clinic of Internal Diseases and Metabolic Disorders, Poznan University of Medical Sciences, Przybyszewskiego 49 Street, 60-355, Pozna, Poland, Tel +4861 8549 377, Fax +4861 8478 529, Email [email protected] Purpose: To compare the efficacy and safety of semaglutide and liraglutide over one year in obese Polish patients with type 2 diabetes

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The GLP-1 receptor agonist liraglutide was able to reduce Bax expression in pancreatic cells from T2DM rats, and Bcl-2 expression was increased, islet tissue structure was improved, insulin-positive expression was increased, and -cell apoptosis was reduced (Liu et al., 2021)