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PeptideDrug Conjugates with Different Linkers for Cancer Therapy
As an important hydrolytic enzyme of ceramides [25], increased Acer2 promotes the hydrolytic metabolism of ceramides, which is an important reason for the significantly decreased ceramide levels observed after hypoxic treatment
The safety profile is strong: toxic doses sit roughly 300 to 3,750 times higher than recommended therapeutic amounts, and injection site irritation remains the most commonly reported side effect
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