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lactis strain, using direct mutagenesis and metabolic engineering for simultaneous overproduction of both folate and riboflavin (Sybesma et al., 2004)

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This is consistent with broader findings that specific probiotic strains, such as Lactobacillus acidophilus LA5 and Lacticaseibacillus rhamnosus GG, can attenuate periodontitis-induced bone resorption and enhance bone regeneration by modulating the gut microbiota and circulating metabolites ( Akkermansia muciniphila , which is often reduced in periodontitis, demonstrates potent anti-inflammatory effects

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