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Some studies suggest the quinolinium structure is sufficiently NNMT-selective that it should not broadly deplete SAM, but the wider metabolic picture remains an active research consideration

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Further Manifestations If the clinical manifestations mentioned above are left unaddressed, they may evolve into further issues (as noted as dark blue boxes in the above graphic)

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Moreover, the HIV infection also causes mild neurocognitive disorder and demyelinating neuropathy with motor and sensory impairments