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Lipid peroxidation is associated with different disease states and is responsible for an unstable cell membrane, oxidation of low-density lipoproteins (LDL) and poly-unsaturated fatty acids (PUFAs)

Moreover, elucidations of epigenetic and gene regulatory mechanisms, such as lnc-HZ06, NCOA4, and IGF2BP3, provide much more profound insights into the ferroptosis-driven molecular pathways and their potential effects on RM

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This reduction activates the Cyclophilin A (CypA)-MMP-9 pathway, which is responsible for the breakdown of the BBB, degeneration of pericytes, and loss of CBF [143, 150,151,152]