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By route of administration, the parenteral segment contributed the highest market share of approximately 88% in 2025
Under ER stress, partner GRP78 binds to unfolded protein, releasing the following three transmembrane receptors: inositol-requiring enzyme 1 (IRE-1), protein kinase-like endoplasmic reticulum kinase (PERK), and activating transcription factor 6alpha, allowing their signaling pathways to be activated
He B, Kemppainen JA, Voegel JJ, Gronemeyer H, Wilson EM
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