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However, some children develop significant obesity, insulin resistance, PMOS (formerly PCOS), prediabetes, or other metabolic conditions where lifestyle changes alone may not be enough

Importantly, specific pharmacological features of tamoxifen, mainly its safety profile associated with only mild side effects, oral bioavailability and wide tissue distribution, make a short-term administration of tamoxifen more desirable as opposed to classical anti-infective agents, such as the antifungal fluconazole and amphotericin B, endowed with scarce diffusion and a high degree of toxicity ( Some pathogen-specific targets have been proposed for tamoxifen antimicrobial activity, such as the calmodulin-dependent signaling pathway in yeast and bacterial cells, the sphingolipid biosynthesis in parasites or viral life cycle proteins ( Tamoxifen Action Against Enveloped Viruses Studies on enveloped viruses provided clear evidence for host-mediated, anti-infective actions of tamoxifen and insights into the molecular mechanisms that might also pertain a wider spectrum of anti-microbial activities

Rights and permissions About this article Cite this article Nauck, M.A., Quast, D.R