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Loren Pickart in 1973, the GHK-Cu copper peptide was isolated based on observations that plasma from younger individuals contained factors that influenced liver cell behavior differently than plasma from older individuals

epithalon and epithalone) is a therapeutic tetrapeptide consisting of the amino acids alanine, glutamic acid, aspartic acid, and glycine

doi: 10.3389/fendo.2025.1530067

Topical GHK-Cu has been used in wound healing and skincare for over three decades with a well-documented safety record

Last reviewed: June 6, 2026 Last updated: June 6, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations