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Janet Woodcock, a retired FDA veteran and former principal deputy commissioner

In addition, P53 can also inhibit system Xc- uptake of cystine by downregulating the expression of SLC7A11, thereby affecting the activity of GPX4, resulting in a reduction in cell antioxidant capacity, accumulation of lipid ROS, and ferroptosis 10,11

Although the axons remain functional and oligodendrocytes remain active in 12-month-old mice, neuronal viability will likely decline due to reduced ATP and increased production of free radicals, perhaps resulting in degeneration with increasing age (Stahon et al., 2016)

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There is also a widely held opinion that an equivalent cytosolic labile heme pool exists and that this pool is important for the intracellular transfer of heme