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By blocking NNMT, it shifts intracellular NAD+ and S-adenosylmethionine (SAM) levels, two cofactors tied to energy metabolism, redox balance, and gene regulation in laboratory models
This matters because many people asking the question yet? are reacting to news that sounds broader than the current reality
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Bills introduced in Congress in 2024 and 2025 (the Treat and Reduce Obesity Act) would change this, but as of April 2026, the bills remain in committee
