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Notably, fecal microbiota transplantation from individuals with MDD into microbiota-depleted rodents induces depressive-like behaviour, accompanied by elevated plasma KYN and increased KYN/TRP ratios [191]
In 2022, SAR441255 (GLP-1/GIP/glucagon receptor triagonist) was administered to obese, diabetic primates and healthy lean to overweight humans without diabetes
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