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A decrease in NAD+ adversely impacts cellular energy metabolism, while a reduction in SAM hinders the activation of genes that are vital for boosting metabolism

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One of the ways to tell if B12 deficency (rather than folate deficiency) is the problem is if any of your symptoms (even tiredness) return before the next injection is due...then improve once you've had an injection

Can I take oral B12 instead of injections

This is one of the core pathological mechanisms underlying obesity, diabetes, and other metabolic diseases