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This structural adjustment has been explored for its potential to retain certain functional properties of FOXO4 while exhibiting a longer stability profile in research settings
Flavonoids ameliorate ototoxic drug-induced hearing impairment by acting as ROS scavengers or inhibitors of JNK, MAPK, and other apoptotic signaling pathways, and by inhibiting aldose reductase activity, xanthine oxidase (Liao et al., 2024), common natural flavonoid mechanisms of action are described below
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