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However, pediatric obesity differs substantially from adult obesity: ongoing growth, nutritional requirements, and psychosocial sensitivity raise concerns regarding potential effects on bone accretion, linear growth, and behavioral adaptation [130]
Epileptic seizures in the rat model of kainic acid-induced epilepsy have been shown to lead to reductions in the hippocampus of the most abundant phospholipid species that contain polyunsaturated fatty acyl chains [114]
Regulatory agencies increasingly recognize the value of surrogate endpoints, adaptive trial designs, and biomarker-driven patient stratification, particularly in areas of high unmet need
Clinicians should take a thorough cardiovascular history and record a baseline heart rate before initiating treatment, and reassess regularly throughout the course of therapy
Again these are reported mechanistic observations within experimental systems
