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Tirzepatide Read the full profile Receptors activated (GIP + GLP-1 (dual)) Molecular weight (4,813.45 Da) Half-life (~5 days) Average weight loss (SURMOUNT-5, 72 wk) (~20%) Typical starting dose (2.5 mg/week) Typical maintenance dose (515 mg/week) Titration schedule (+2.5 mg every 4 weeks) Given as a weekly shot Available forms (Injection only) FDA-approved (Mounjaro/Zepbound) Brand-name price (no insurance) ($1,000+/month) Compounded price (where available) ($125$278/month) Shared GI side effects (nausea, etc.) Approved for sleep apnea Semaglutide Read the full profile Receptors activated (GLP-1 only) Molecular weight (4,113.64 Da) Half-life (~7 days) Average weight loss (STEP 1, 68 wk) (~15%) FDA-approved for cardiovascular risk reduction Typical starting dose (0.25 mg/week) Typical maintenance dose (2.4 mg/week) Titration schedule (+0.250.5 mg every 4 weeks) Given as a weekly shot Available forms (Injection or oral tablet (Rybelsus)) FDA-approved (Ozempic/Wegovy) Brand-name price (no insurance) ($1,000+/month) Compounded price (where available) ($99$178/month) Shared GI side effects (nausea, etc.) Our top-rated vendor Our rankings are based solely on third-party lab testing rigor, COA transparency, and pricing no paid placements, no affiliate influence

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Drug-Drug Interaction Concerns A comprehensive review published in Drug Design, Development and Therapy examined pharmacokinetic drug-drug interactions for approved GLP-1 receptor agonists

Why Protein-First Eating Matters So Much on a GLP-1 GLP-1 medications slow digestion and suppress appetite, which is exactly why they work for weight loss, but it also means most people are eating dramatically less food overall