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Although GLP-1RAs improve mobility and reduce body weight, some patients decrease physical activity during treatment due to fatigue or altered energy perception

5 mg vials are typically used in shorter studies or for smaller animal models

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Early benefits may have been symptomatic, not disease-modifying In the initial trials, patients on exenatide ended with better MDS-UPDRS-3 motor scores than at baseline , a surprising finding for a disease-modifying drug