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A study by Mass Eye and Ear (which was published in JAMA Ophthalmology) found that those on semaglutide were four times more likely to develop NAION (17 of 200 diabetes patients) and seven times more likely to develop NAION if they were also obese or overweight (20 of 361 overweight or obese patients)
Pesq Vet Bras 35:353359
An important consideration is that GLP-1 receptor agonists delay gastric emptying and intestinal transit (Meloni et al
Caution is advised in patients with a history of pancreatitis, as semaglutide has been associated with an increased risk of this condition
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