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Rather than copying GHRH, it mimics ghrelin, the so-called hunger hormone, and binds the growth hormone secretagogue receptor (GHS-R1a), also called the ghrelin receptor

2D two-dimensional hiPSC human induced pluripotent stem cell 3D three-dimensional hPSCs human pluripotent stem cells AAV adeno-associated virus HUVECs human umbilical vein endothelial cells ADPKD autosomal dominant polycystic kidney disease iETV2-hiPSCs inducible ETV2-expressing human induced pluripotent stem cells AI artificial intelligence iPSC induced pluripotent stem cell AKI acute kidney injury NF-B nuclear factor kappa-light-chain-enhancer of activated B cells ALI air-liquid interface NGAL neutrophil gelatinase-associated lipocalin cAMP cyclic adenosine monophosphate PBMCs peripheral blood mononuclear cells CKD chronic kidney disease pFSGS primary focal segmental glomerulosclerosis CRISPR/Cas9 clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 ROS reactive oxygen species ECM extracellular matrix scRNA-seq single-cell RNA sequencing ESC embryonic stem cell TCBs T cell bispecific antibodies ESRD end-stage renal disease TGF-1 transforming growth factor beta 1 EZH2 enhancer of zeste homolog 2 VEGF vascular endothelial growth factor Glossary References 1

FIGURE 1 3.2.1 Antioxidant activity One of the main mechanisms of flavonoids is their powerful antioxidant properties

At the same time, personalized microbiota-directed interventions targeting specific metabolic or ecological functional deficits represent another important direction [475, 476]

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