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5 This can have significantly detrimental effects on the nervous system, cell division, and other methylation processes

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Haematological Isolated red cell macrocytoisis Macrocytic anaemia (especially if MCV more than 110fl) Pancytopenia (especially if MCV more than 120fl) Neurological or Psychiatric Optic neuropathy Peripheral neuropathy (sensory or motor) Symmetrical neuropathy affecting the legs more than the arms

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Serious deficiency can impair heart and neurological function, leading to a wide range of symptoms, including tinnitus, severe joint pain, memory problems, depression, anxiety and poor muscle function