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Why the Glutathione Index Is the Best Indicator of Brain Oxidative Stress The GSH/GSSG ratio reflects the activity of the enzyme glutathione reductase which is responsible for the transformation of GSSG (used, oxidised) to GSH (the reduced or fully loaded form that acts as a radical scavenger)

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It helps neutralize unstable molecules known as free radicals and works alongside other antioxidants in the body

and glutathione synthetase that in a second step combines -glutamyl-cysteine with glycine for forming GSH (Figure 3)