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After 48 weeks, Retatrutide achieved 24.2% weight loss in obese or overweight patients and produced 17% weight loss in diabetic patients, making it arguably the most powerful pipeline today

Heres a look at common biologic classes and their half-lives: o Humira (adalimumab): 68 weeks o Enbrel (etanercept): 2 weeks o Remicade (infliximab): 46 weeks o Cosentyx (secukinumab): 4 weeks o Stelara (ustekinumab): 12 weeks o Tremfya (guselkumab): 8 weeks o Xeljanz (tofacitinib): 12 weeks o Rinvoq (upadacitinib): 12 weeks A common approach physicians might take to accommodate for the variation in drug half-lives is to stop one full dosing interval before major implant surgery for each biologic, with consideration for a longer hold where theres a high risk for infection or poor wound healing

Randomized Withdrawal, Selected Entrants STEP 4 is often compressed into a single before-and-after statistic

Cracks in the viewing window or damage to the injection mechanism mean the pen should not be used