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Participants were randomized to placebo or retatrutide at 1 mg, 4 mg (dose-escalation), 4 mg (no escalation), 8 mg (escalation), 8 mg (no escalation), or 12 mg (escalation) for 48 weeks, following a slow titration protocol

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While some providers recommend brushing before dosing to prepare the mucosa, aggressive brushing can actually cause bleeding or irritation that changes absorption patterns

Water molecules are omitted for clarity

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