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This further highlights the important biosynthetic role of G6PD in cell survival and proliferation 87,93,94
Depletion of cellular antioxidant defences, such as GSH, results in accumulation of ROS, loss of mitochondria function and thus induction of cell death
The epigenetic study has found that Hcy induces DNA hypomethylation of the cyclin A promoter by downregulating the expression of DNA methyltransferase 1 (DNMT1) to inhibit endothelial progenitor cells (EPCs) proliferation (108)
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