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Tirzepatide is available in Scotland to people with a BMI of 30 or more, or between 2730 if they have at least one weight-related comorbidity, such as hypertension, cardiovascular disease, or type 2 diabetes mellitus 43

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Moreover, as understanding of GLP-1 biology expands, researchers are also investigating its effects on the gut-brain axis

John Buse, who has served as a principal investigator in multiple semaglutide trials, noted: "The glycemic efficacy of semaglutide is remarkably consistent across age subgroups, and we do not titrate differently for a 35-year-old versus a 55-year-old." Glycemic Outcomes: What the SUSTAIN Trials Show The SUSTAIN program comprises multiple phase 3 trials that established semaglutide's efficacy and safety profile