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The American Diabetes Association notes that GH excess (as seen in acromegaly) causes frank diabetes in approximately 20-30% of patients [11], a caution that extends by mechanism to prolonged secretagogue use

Gastroenterology 152, 16791694.e3

In late 2023, the FDA added more than a dozen peptides including both BPC-157 and thymosin alpha 1 to its list of substances that should not be compounded because the agency has identified potential significant safety risks. For BPC-157, the agency warned that the peptide could trigger an immune response

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