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Carnitine promotes the influx of Ca 2+ from the extracellular environment through the depolarization of L-type Ca 2+ channels, providing an impetus for the initial activation of intracellular calcium signaling

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The expression and activation of EGFR are positively correlated with the airway epithelial goblet cell proliferation and mucus production

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[42] [43] Half-life is determined by clearance (CL) and volume of distribution (V D ) and the relationship is described by the following equation: In clinical practice, this means that it takes 4 to 5 times the half-life for a drug's serum concentration to reach steady state after regular dosing is started, stopped, or the dose changed