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Tirzepatide data from SURMOUNT-1 showed constipation in roughly 10-17% of participants depending on dose
received consultant honoraria from Novo Nordisk and CVS Caremark, which is unrelated to the current study
This dual mechanism produces even stronger appetite suppression and weight loss results in clinical trials
Interestingly, these drugs also have a major benefit on cardiovascular disease outcomes and are approved to reduce major adverse cardiovascular events in type 2 DM patients with CV disease and independently in heart failure patients
Instead, they lose weight gradually for months or even years
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