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For example, vitamin C, through its antioxidant properties, can neutralize free radicals through different mechanisms including the elimination of free radicals and reactive oxygen or nitrogen species, the down-regulation of enzymes producing free radicals, and the modulation of Nuclear Factor Erythroid 2-Related Factor and Nuclear Factor Kappa B (NF-B), which are important mediators in oxidative stress (44)

Thus, by promoting intimal hyperplasia, these vascular disorders (which are related to smooth muscle cell proliferation, collagen accumulation, and the extracellular matrix modification that may result from homocysteinylation of the vascular wall structure leading to connective tissue deterioration) might contribute to the atherogenic tendency of hyperhomocysteinemia

The inconsistent results are likely due to differences in the dose, duration, specific compounds used (DHA vs

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