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Most patients experience significant weight regain after stopping GLP-1 medications, with clinical trials showing regain of substantial weight within the first year
Sandoval-Acuna C, et al
By comparison, GLP-1 monotherapy alone achieves 14.9% (STEP 1) to 20.9% (SURMOUNT-1) of body weight loss
Semaglutide activates only GLP-1R
Creating a written action plan during stable periods provides a roadmap for crisis times
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