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Although studies have confirmed that the three components form a positive-feedback loop that drives DR progression and that antioxidant therapy can alleviate DR pathology, the key molecular triggers that initiate the loopsuch as the cell-specific mechanisms by which hyperglycemia induces excessive ROS production in different retinal cellsremain poorly defined

Without protein-sparing measures, studies suggest 2040% of total weight lost on GLP-1 therapy can be lean mass

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This extra mechanism provides the following benefits: Greater appetite suppression and glucose control due to additive effects when combined with GLP-1 agonism Improving how fat cells respond to insulin , which provides more effective blood sugar control Promoting the breakdown of fat cells resulting in more effective weight loss How effective are GLP-1 medications