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Griebeler, MD and Bartolome Burguera, MD, PhD., Should I consider metformin therapy for weight loss in patients with obesity but without diabetes
Significant prior efforts across the pharmaceutical industry have failed to identify potent and efficacious small-molecule agonists of the GLP-1R ( 15, 16 )
42 In the STEP 1 study, participants who achieved a mean weight loss of 10.6% after 20 weeks of semaglutide were rerandomized in STEP 4 to either continue semaglutide or switch to placebo for an additional 48 weeks
According to Health Magazine , experts note that some patients see improved results as their dosage increases under medical supervision
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