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Description

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Analytical workflows commonly combine reversed-phase LC separation, high-resolution mass spectrometry (HRMS), and tandem MS fragmentation to detect low-level impurities and structural modifications

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Several complex signal transduction pathways and cellular processes have been implicated in APAP hepatotoxicity, including those involving c-Jun N-terminal kinase, Nuclear factor E2-related factor 2 (Nrf2), p53, endoplasmic reticulum stress, autophagy, and sterile inflammation (Chowdhury et al

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FernandoKConnollyDDarcyEEvansMHinchliffeWHolmesPet al

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