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Most GI symptoms were mild to moderate and diminished by week 12 to 16
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For oral semaglutide (Rybelsus), specific administration timing is critical: take once daily on an empty stomach with no more than 4 ounces of plain water, then wait at least 30 minutes before eating, drinking, or taking other oral medications
Therefore, we assumed that the disappearance of GLA protein in Clone #5 was due to the early stop codon and that the minimal mRNA expression in Clone #9 resulted in a low amount of GLA protein (Fig
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