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In vitro, it upregulates extracellular matrix genes (COL1A1, elastin, decorin) while suppressing inflammatory cytokines

While some research shows a preference for bioidential forms of B12, theres a synthetic form of B12 called cyanocobalamin that is also considered acceptable

Toxic overload does not explain every case of depression, but oxidative stress, inflammation, mitochondrial dysfunction, medication sensitivity and impaired methylation may contribute to depressive symptoms in selected patients

And they might not have a trusted medical provider to contact if they have questions or, even worse, if something goes wrong