However, the relevance of these findings to humans remains uncertain because human thyroid C-cells express GLP-1 receptors at much lower levels than rodent C-cells, suggesting potentially different susceptibility to GLP-1-mediated effects
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As of January 2026, 13 states (Delaware, Kansas, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, North Carolina, Rhode Island, Tennessee, Utah, Virginia, and Wisconsin) cover GLP-1 receptor agonists (such as Wegovy) for weight loss
Scientific References Berberine as a Bioactive Alkaloid: Multi-Omics Perspectives on Its Role in Obesity Management
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