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Sobia Sadiq, triple board-certified in Internal Medicine, Endocrinology, and Obesity Medicine, and I have been prescribing GLP-1 medications for over a decade
First, in composite outcomes such as MACE, differences in definition introduce heterogeneity in the analysis as seen in Supplementary Material 2
Their effects on GLP-1 are subtle compared to pharmaceutical options
miRNAs that regulate the IGF-1 signaling are prime targets for the development of novel therapies for several disease including cancer ( Table 1 )
Whilst the market is currently led by Novo Nordisks semaglutide (Ozempic/Wegovy) and Eli Lillys tirzepatide (Mounjaro/Zepbound), stronger competition is expected as new entrants including Boehringer Ingelheim, Amgen, Pfizer and Roche offer novel mechanisms (dual agonists, triple agonists and amylins), formulations (oral vs injectable) and dosing regimens (daily vs weekly vs monthly)
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