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Roughly 12.7% of users are diagnosed with a nutritional deficiency within six months of starting treatment, and that climbs to 22.4% by the 12-month mark, according to a 2025 claims analysis of more than 460,000 GLP-1 users [3]
Secondly, the high polarity, low oral bioavailability, and short half-life of safflower yellow pigments pose key challenges to their oral use
& Wang, Z
Lancet Psychiatry 8 , 969980 (2021)
The simultaneous activation of these pathways results in a multi-dimensional approach to metabolic regulation
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