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Your physician may assess whether you are achieving expected weight loss (typically at least 5% of initial body weight after 3 months on a maintenance dose), as persistent hunger without weight loss suggests suboptimal therapeutic effect

Similarly, the estimated treatment difference in STEP 1 was 12.4% compared with 19.1% in BARI-STEP, which was designed based on the STEP 1 trial

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It becomes more sensitive to temperature and light

Additional studies are needed to determine whether SGLT2 inhibitors can meaningfully delay kidney disease progression in people with non-albuminuric or non-proteinuric DKD