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Animal Model and Ethics Statement Wistar rats from the breeding colony at the Universidade do Extremo Sul Catarinense (UNESC), Brazil, were housed four times per cage under controlled conditions of temperature (22 1 C), relative humidity (4555%) and light-dark cycle (12:12 p.m., light on at 6 a.m.)
Full transformation of normal cells to a cancerous phenotype is a multi-step process (Hanahan and Weinberg 2011
ALADIN III Study Group
Eighteen adult, female New Zealand white rabbits, all physically normal and weighing an average of 2.5 kg, were used
Helps in wound healing and connective tissue formation
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